GW501516, a PPAR-BETA/DELTA agonist, improves inflammatory pathways in the kidney of high-fructose fed mice
نویسندگان
چکیده
Materials and methods To induce high activation of this receptor, mice were fed a high-fructose diet for eight weeks. The control group only received standard-chow (SC). After, the animals were randomly divided into four groups and the administration of GW501516 started and lasted three weeks. Morphological variables and urinary and plasmatic determinations were assessed. Renin and angiotensin converting enzyme (ACE)/AT1r axis protein and gene expression were evaluated as well as inflammatory cytokines and proteins. Also, the protein and gene expression of the antioxidant enzymes were verified.
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2015